Profile photo of nadhwiki

nadhwiki has written 69 articles

NADPH, a directly operating antioxidant

NADPH, a directly operating antioxidant ABSTRACT Endogenous oxygen- and nitrogen-centered free radicals are considered to play a decisive role in a variety of diseases such as neurodegenerative disorders, atherosclerosis, or cancer. Directly operating antioxidants limit the action of freely diffusing radicals by scavenging the attacking, oxidizing radical and rereducing the oxidized biomolecule, i.e., the biomolecule-…

NADNADH and NADPNADPH in Cellular Functions and

NADNADH and NADPNADPH in Cellular Functions and ABSTRACT Accumulating evidence has suggested that NAD (including NAD and NADH) and NADP (including NADP and NADPH) could belong to the fundamental common mediators of various biological processes, including energy metabolism, mitochondrial functions, calcium homeostasis, antioxidation/generation of oxidative stress, gene expression, immunological functions, aging, and cell death: First,…

The malate–aspartate NADH shuttle

The malate–aspartate NADH shuttle Recent studies suggest that increased mitochondrial metabolism and the concomitant decrease in NADH levels mediate calorie restriction (CR)-induced life span extension. The mitochondrial inner membrane is impermeable to NAD (nicotinamide adenine dinucleotide, oxidized form) and NADH, and it is unclear how CR relays increased mitochondrial metabolism to multiple cellular pathways that…

Nampt_ Linking NAD biology, metabolism, and cancer

Nampt_ Linking NAD biology, metabolism, and cancer Abstract Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide to nicotinamide mononucleotide (NMN), a key NAD intermediate. Previously identified as a cytokine PBEF and controversially claimed as an insulin-mimetic hormone visfatin, Nampt has recently drawn much attention in different fields, including NAD biology, metabolism, and inflammation. As an NAD biosynthetic enzyme,…

Nadh_Sensor of blood flow need

Nadh_Sensor of blood flow need ABSTRACT The sensor for blood-flow need with neural activity and exercise is not known. We tested the hypothesis that accumulation of electrons in cytosolic free nicotinamide adenine dinucleotide (NAD) activates redox signaling pathways to augment blood flow. NAD is the primary carrier of electrons from glucose and lactate for ATP…

NADH_neue Wege in der behandlung des klimakterischen Syndroms

NADH_neue Wege in der behandlung des klimakterischen Syndroms Einleitung Klimakterisches Syndrom Laut einer Fragebogenumfrage1 über das Belastungspotenzial von Wechselbeschwerden an 667 Frauen in Österreich stehen Hitzewallungen, Schweißausbrüche und die Trockenheit der Haut an der Spitze des Symptomenkomplexes; weitere Beschwerden waren Schlafstörungen, Störungen im Bereich des Wohlbefindens, depressive Verstimmung und Antriebsschwäche. Das Auftreten und die Stärke…

NADH_NAD redox state of cytoplasmic glycolytic

NADH_NAD redox state of cytoplasmic glycolytic Barron, John T., Liping Gu, and Joseph E. Parrillo. NADH/NAD redox state of cytoplasmic glycolytic compartments in vascular smooth muscle. Am J Physiol Heart Circ Physiol 279: H2872–H2878, 2000.—The cytoplasmic NADH/ NAD redox potential affects energy metabolism and contractile reactivity of vascular smooth muscle. NADH/NAD redox state in the…

NADH the energizing coenzyme

NADH the energizing coenzyme NADH is the abbreviation for the biological substance nicotinamide adenine dinucleotide. The “H“ stands for high-energy hydrogen and indicates that it is the reduced form of coenzyme 1, another term for NADH. Enzymes catalyze biological processes and create products in our body which we need to survive. They can be compared…