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nadhwiki has written 69 articles

NADH supplementation decreases pinacidil-primed

NADH supplementation decreases pinacidil-primed Abstract The aim of this study was to investigate the effect of NADH-supplementation on the metabolic condition of isolated guinea pig ventricular cardiomyocytes using the pinacidil-primed IK(ATp) as an indicator of subsarcolemmal ATP concentration. Membrane currents were studied using the patch-clamp technique in the whole-cell recording mode at 36-37oC. Under physiological conditions (4.3 mM ATP…

NADH stimulates endogenous dopamine biosynthesis

NADH stimulates endogenous dopamine biosynthesis Abstract Treatment of Parkinson patients with L-DOPA 3,4-dihydroxy-L-phenylalanine. leads to endproduct inhibition of tyrosine hydroxylase, the key enzyme in dopamine biosynthesis and the enzyme needing tetrahydrobiopterin and iron as cofactors. To overcome this problem an alternative treatment was investigated which attempted to stimulate endogenous dopamine biosynthesis. Incubation of rat PC…

NADH Shuttle and Insulin Secretion

NADH Shuttle and Insulin Secretion In their report (1), Eto et al. hypothesize that nicotinamide adenine dinucleotide (NADH) is the signal for the coupling of glycolytic and mitochondrial glucose metabolism that triggers insulin secretion. Their conclusions, based on their innovative and meticulous experiments, do not consider the possibility that the glycolytic end-product in the cytosol…

NADH in Cancer Prevention

NADH in Cancer Prevention All living cells require energy to stay alive. Without energy, a cell dies because the energy production represents the essential prerequisites for every living cell. How is energy produced in the cell? NADH reacts with oxygen to produce in a cascade of biochemical reactions producing water and energy. This energy is…

NADH augments blood flow in physiologically activated retina and visual cortex

NADH augments blood flow in physiologically activated retina and visual cortex The mechanism(s) that increase retinal and visual cortex blood flows in response to visual stimulation are poorly understood. We tested the hypothesis that increased transfer of electrons and protons from glucose to cytosolic free NAD, reducing it to NADH, evoked by increased energy metabolism,…

nadh and calcium

nadh and calcium As an important second messenger, calcium triggers a broad range of energy-consuming cellular reactions like contraction, secretion and gene expression (Clapham, 1995; Berridge et al. 1998; Brini & Carafoli, 2000). To match the increased energy demand, calcium simultaneously upregulates the rates of NADH production and ATP synthesis (McCormack et al. 1990; Hajnoczky…