NAD and Vitamin B3

NAD and Vitamin B3

ABSTRACT
The role of NAD metabolism in health and disease is of increased
interest as the use of niacin (nicotinic acid) has
emerged as a major therapy for treatment of hyperlipidemias
and with the recognition that nicotinamide can protect tissues
and NAD metabolism in a variety of disease states, including
ischemia/reperfusion. In addition, a growing body of evidence
supports the view that NAD metabolism regulates important
biological effects, including lifespan. NAD exerts potent effects
through the poly(ADP-ribose) polymerases, mono-ADPribosyltransferases,
and the recently characterized sirtuin enzymes.
These enzymes catalyze protein modifications, such as
ADP-ribosylation and deacetylation, leading to changes in protein
function. These enzymes regulate apoptosis, DNA repair,
stress resistance, metabolism, and endocrine signaling, suggesting
that these enzymes and/or NAD metabolism could be
targeted for therapeutic benefit. This review considers current
knowledge of NAD metabolism in humans and microbes,
including new insights into mechanisms that regulate NAD
biosynthetic pathways, current use of nicotinamide and nicotinic
acid as pharmacological agents, and opportunities for
drug design that are directed at modulation of NAD biosynthesis
for treatment of human disorders and infections…

nadhwiki has written 69 articles

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