NAD metabolism in health and disease

NAD metabolism in health and disease

Nicotinamide adenine dinucleotide (NAD+) is both a
coenzyme for hydride-transfer enzymes and a substrate
for NAD+-consuming enzymes, which include ADPribose
transferases, poly(ADP-ribose) polymerases,
cADP-ribose synthases and sirtuins. Recent results
establish protective roles for NAD+ that might be applicable
therapeutically to prevent neurodegenerative conditions
and to fight Candida glabrata infection. In
addition, the contribution that NAD+ metabolism makes
to lifespan extension in model systems indicates that
therapies to boost NAD+ might promote some of the
beneficial effects of calorie restriction. Nicotinamide
riboside, the recently discovered nucleoside precursor
of NAD+ in eukaryotic systems, might have advantages
as a therapy to elevate NAD+ without inhibiting sirtuins,
which is associated with high-dose nicotinamide, or
incurring the unpleasant side-effects of high-dose
nicotinic acid…

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