nadh and calcium

nadh and calcium

As an important second messenger, calcium triggers a
broad range of energy-consuming cellular reactions like
contraction, secretion and gene expression (Clapham,
1995; Berridge et al. 1998; Brini & Carafoli, 2000). To match
the increased energy demand, calcium simultaneously
upregulates the rates of NADH production and ATP
synthesis (McCormack et al. 1990; Hajnoczky et al. 1995;
Robb-Gaspers et al. 1998; Jouaville et al. 1999). Mitochondria
are capable of decoding – converting calcium signals into
changes in energy production (Hajnoczky et al. 1995;
Jouaville et al. 1999). In other words, calcium is an essential
regulator of mitochondrial metabolism (McCormack et al.
1990; Duchen, 2000a; Rizzuto et al. 2000). Abnormalities
of calcium signalling can trigger varied forms of
mitochondrial pathology (Brini et al. 1999; Szalai et al.
1999; Duchen, 2000b)…

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