Nampt_ Linking NAD biology, metabolism, and cancer

Nampt_ Linking NAD biology, metabolism, and cancer

Abstract
Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide to nicotinamide
mononucleotide (NMN), a key NAD intermediate. Previously identified as a cytokine PBEF and
controversially claimed as an insulin-mimetic hormone visfatin, Nampt has recently drawn much
attention in different fields, including NAD biology, metabolism, and inflammation. As an NAD
biosynthetic enzyme, Nampt regulates the activity of NAD-consuming enzymes such as sirtuins and
influences a variety of metabolic and stress responses. Nampt also plays an important role in the
regulation of insulin secretion in pancreatic β cells. Nampt appears to have another function as an
immunomodulatory cytokine and plays a role in inflammation. This review summarizes these various
functional aspects of Nampt and discusses its potential roles in diseases, including type 2 diabetes
and cancer…

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