Author: nadhwiki Page 6 / 7

Der vasodilatatorische Effekt der Aminosäure L-Arginin Einleitung I.1 Historisches Anfang der achtziger Jahre bemerkte die Forschergruppe Furchgott u. Zawadski, dass trotz der stark ausgeprägten vasodilatatorischen Eigenschaften von Acetylcholin in vivo, an isolierten Blutgefäßpräparationen es nicht immer zu einer Relaxation kam. Sie bemerkten, dass während der Herstellung der Blutgefäßpräparate unabsichtlich hierbei die Intimaoberfläche verletzt wurde. Jedoch…

Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2_ Evidence for acetyl transfer from substrate to an NAD breakdown product The Saccharomyces cerevisiae silencing protein Sir2 is the founding member of a universally conserved family of proteins that have been shown to possess NAD-dependent histone deacetylation and ADP-ribosylation activities. Here we…

Correlation of NADH and Ca2+ signals Relationships between calcium signals and NADH responses were investigated in pancreatic acinar cells stimulated with calcium-releasing secretagogues. Cytosolic calcium signals were studied using Fura Red or calcium-sensitive Cl_ current. Mitochondrial calcium was measured using Rhod-2. The highest levels of NADH autofluorescence were found around the secretory granule region. Stimulation…

Coenzyme Nicotinamid Dinukleotid Hydrogen_ Therapeutic Potential

Coenzym1 eine wissenschaftlich bewiesene Zusommenfossungcr oenzym-r,a uchu nter NADH bekannt,i st das wichtigste Coenzym, denn es produziert in jeder ZeLleÄTp-Energie. DiesesP hänomeni st an isoliertenH erzzellenb ewiesenw orden. versetztm an diesem it NADH, erhöht sichd erA Tp-Spiegeiln der Zelle. Auch die vitalität der Herzzellen liegt nach NADH-zugabe deutlichh öhera lso hneN ADH. Eine gleichartigeÄ Ip…

Vitamin_B3_and_NADH_for_Dementia Abstract Dementia affects approximately 5 million people in the United States, and about 475,000 elderly Canadians. Dementia is a debilitating and often progressive illness. The most common type of dementia is Alzheimer’s disease, followed by vascular types. There is a need to investigate novel treatments because the current crop of medications have limited value.…

Untersuchungen zur Pharmakokinetik von NADH in vivo und in vitro 1. Einleitung Nicotinamid-adenin-dinucleotid (NADH) spielt als Elektronen-Transportmolekül eine zentrale Rolle im Energiestoffwechsel aller Lebewesen. Bruttoenergie wird in Form von Nahrung aufgenommen, die erst über zahlreiche Zwischenschritte in die physiologisch nutzbare Energiequelle Adenosintriphosphat (ATP) umgewandelt werden muss, bevor sie ihre eigentliche Funktion erfüllen kann. Die Energie…

Characterization of NAD Uptake in Mammalian Cells Recent evidence has shown that NAD(P) plays a variety of roles in cell-signaling processes. Surprisingly, the presence of NAD(P) utilizing ectoenzymes suggests that NAD(P) is present extracellularly. Indeed, nanomolar concentrations ofNADhave been found in plasma and other body fluids. Although very high concentrations of NAD have been shown…

Capsaicin inhibits preferentially the NADH oxidase and growth of transformed cells in culture ABSTRACT A hormone- and growth factor-stimulated NADH oxidase of the mammalian plasma membrane, constitutively activated in transformed cells, was inhibited preferentially in HeLa, ovarian carcinoma, mammary adenocarcinoma, and HL-60 cells, all of human origin, by the naturally occurring quinone analog capsaicin (8-methyl-N-vanillyl-6-…

Calorie restriction extends yeast life span by lowering the level of NADH Calorie restriction (CR) extends life span in a wide variety of species. Previously, we showed that calorie restriction increases the replicative life span in yeast by activating Sir2, a highly conserved NAD-dependent deacetylase. Here we test whether CR activates Sir2 by increasing the…